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We are seeking a highly motivated Principal Scientist to join the Analytical Chemistry Group of Regeneron Pharmaceuticals, Inc. located at Tarrytown, NY, which develops innovative mass spectrometry-related technologies to support Regeneron R&D programs. In this role you will lead analytical development of therapeutic protein drug candidates to support all stages of drug development, from early-stage candidate selections to late-stage regulatory submissions.

Job Duties: A Typical Day Might Look Like:

• Leads characterization of biotherapeutics, including monoclonal antibodies, bispecifics, adeno-associated virus and other biotherapeutic candidates

• Is accountable for the development of analytical strategies and methods to elucidate and determine the quality attributes, risk assessment and control strategies, including PTMs, product and process related impurities, especially for host cell proteins (HCPs), charge variants, LMW/HMW species, sequence variants, etc., to address emerging challenges;

• Provides analytical guidance and support for formulation development, upstream and downstream functional groups, manufacturing to solve real-time development issues in the process development and OOT/OOS investigations

This Role Might Be For You If You Have:

• Excellent oral and written communication skills and interpersonal skills

• Experience in composing regulatory submission documents and knowledge in the industry practice and regulatory mentorship on analytics development

• Passion in science with strong leadership and motivation of making contributions in a collaborative setting

This role requires PhD in chemistry, biochemistry or other related fields with a minimum of 3+ years of proven experience, and a record of publications in the field. A strong background in liquid chromatography and mass spectrometry with biopharma experience especially in protein therapeutics or AAV, RNA analytics is helpful. Expertise in mass spectrometry principles and applications for protein characterization and process development, with keen analytical and problem-solving skills, especially for Orbitraps, Triple-quadruple MS systems desired. Experience with analyzing trace amount samples such as single cell is good to have. Proficiency in LC and MS-related software, such as Xcalibur, MassLynx, MassHunter, Proteome Discoverer, Byonics, Skyline, Empower desired. Experience in DIA data analysis is a plus.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)

$124,200.00 - $202,800.00