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Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

The Cancer Immunology and Cellular Therapy Thematic Research Center (CICT) is one of the fundamental research and early development engines delivering therapeutics to patients. Our mission is to drive leadership in the use of immune effector cell-based therapies in hematological and solid cancers. Within CICT, t he Cell Therapy Process Research and Engineering (CT-PRE) team works at the exciting interface of engineered T-cell biology and cell therapy process development, in close collaboration with colleagues across the Research and Development organizations, with the goal of advancing novel innovative platforms from early concept design towards implementation for pipeline assets.

Position Responsibilities

The CT-PRE team is seeking a highly motivated, dynamic, self-driven and collaborative individual to contribute to the exploration and early process development of next generation cell therapies. This team is responsible for accelerating the assessment of novel drug assets in the preclinical pipeline from research to full development. In the Sr. Scientist role, the successful candidate will lead a team of two scientists/engineers with a lead-from-the-bench approach and focus on developing and implementing clinical scale technologies for gene-edited cell therapy manufacturing processes. The candidate will collaborate cross-functionally to assess the scalability, integration and adoption of new technologies into existing and new gene-edited platforms for pipeline assets.

The ideal candidate will have a strong background in clinical/manufacturing scale process development for CAR-T cell therapy, prior experience with and understanding of key challenges related to the scaling up and closing of workflows in gene delivery, editing, activation, selection, washing and other technologies. A deep understanding of T cell biology and cancer immunology, and a solid grasp on gene editing techniques are essential skills. This role will provide a challenging but rewarding opportunity for career development in a fast-paced environment and is ideal for a scientist/bioengineer with an innovative cell engineering mindset. A previous experience in the cell therapy industry is highly preferred.

In the role as a Senior Scientist, the ideal candidate:

• Leads from the bench and applies scientific and / or technical skills and functional knowledge to design and conduct experiments and research projects pertaining to viral and non-viral based gene-edited cell therapy engineering.

• Evaluates manufacturing-scale feasibility/performances of research-scale proof-of-concepts and provides inputs on manufacturability success.

• Informs CMC strategy and defines phase-appropriate process development technical roadmaps based on program timelines.

• Works to develop clinical/manufacturing scale processes and build early process understanding, in close collaboration with colleagues in the Development and Research organizations.

• Works cross-functionally to align and execute seamless transition of process automation and integration technology strategies for new platforms and/or assets.

• Applies statistical experimental design frameworks (e.g. DoE) to conduct studies exploring a large multi-factorial design space.

• Leads discussions and makes presentations in multidisciplinary meetings, logically presenting information to convey clear, key messages.

• Works proactively to engage all stakeholders cross-functionally to collect inputs and feedback.

Key Responsibilities

• Work primarily in the laboratory under minimal supervision.

• Generate data to support the development of clinical flow cytometry assays. Activities include, but are not limited to, assay design, optimization, and qualification.

• Utilize analytics tools to ensure the quality of flow cytometry data in preparation for downstream analysis. Support data analysis and interpretation.

• Provide support for critical reagent management, including assay controls and custom antibodies, ensuring the reagents are properly handled, stored, and tracked.

• Perform routine maintenance on flow cytometry instruments, troubleshoot issues and communicate with field application scientists as needed.

• Implement and oversee flow cytometry assays for clinical sample testing at external lab partners.

• Maintain effective communications with our external lab partners.

• Must be able to set and understand priorities in a local and matrixed environment, must be a team player with a collaborative spirit, and capable of maintaining networks within and outside the organization.

• Perform other tasks as needed to support the team and program objectives.

Basic Qualifications:

• Bachelor's Degree

• 7+ years of academic and / or industry experience

Or

• Master's Degree

• 5+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences

• 2+ of academic and / or industry experience

Preferred Qualifications

• Experience in clinical manufacturing scale processes and aseptic cell handling, for unit operations on gene delivery and editing, selection, activation, expansion of primary immune cells is highly desired.

• Experience with gene editing technologies (CRISPR-based), using viral (AAV) and non-viral (electroporation, lipid nanoparticles, etc.) delivery mechanisms in immune cells.

• Experience taking research/bench scale proof-of-concept demonstrations and scaling/developing for platform implementation.

• Hands-on experience working with various manufacturing-scale, closed-system cell processing technology and equipment.

• Familiarity with process automation and integration.

• Sound conceptual understanding of and ability to interpret results from cellular and molecular analytical techniques, like multi-parameter flow cytometry, Incucyte-based assays, cytotoxicity assays, ddPCR, NGS, qPCR, etc.

• Demonstrated ability to lead and effectively manage a small team.

• Ability to multitask, independently organize time, and plan specifics of work.

• Excellent communication and facilitation skills demonstrated in a team environment.

• Willingness to think outside the box, be creative and ability to work in a very fast paced, ever changing environment.

The starting compensation for this job is a range from $108,000 - $135,000 plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.

Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

*LI-Onsite

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Company: Bristol-Myers Squibb

Req Number: R1581900

Updated: 2024-06-17 04:05:46.787 UTC

Location: Seattle-WA

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.