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Reference #: 1010676 SHIFT:Day (United States of America)

Seeking Breakthrough Makers

Children's Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care-and your career.

CHOP's Commitment to Diversity, Equity, and Inclusion

CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.

We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.

A Brief Overview A position is available in the laboratory of Ethan M. Goldberg, M.D., Ph.D., in the Division of Neurology at The Children's Hospital of Philadelphia. The lab studies mechanisms of epilepsy and neurodevelopmental disorders using a range of techniques, including: human and mouse genetics; neurons and organoids generated from induced pluripotent stem cells from human patients with neurodevelopmental disorders; electrophysiology including voltage clamp of ionic currents in heterologous systems and acute brain slice in mouse; advanced microscopy including two-photon calcium imaging in vivo; and animal behavior.

The applicant will work with the Principle Investigator and research laboratory to lead a project(s), conduct experiments, generate data for manuscripts and grant applications, train and mentor undergraduate and graduate students, and maintain major equipment. The ideal candidate will be experienced, enthusiastic, self-driven, and committed to learning and working as part of a team. Specific prior experience with animal handling, animal surgeries such as stereotaxic injection; ion channel, cellular, and synaptic neurophysiology; and/or in vivo two-photon calcium imaging; is required. She or he will have excellent data recording, organizational, and communication skills, and the ability to multi-task.

What you will do Animal (mouse) husbandry (breeding, handling, surgical procedures, and genotyping) and colony maintenance Immunohistochemistry (mouse perfusion and fixation; vibratome, sliding microtome, and/or cryostat sectioning; light and confocal microscopy) Mouse behavioral training Molecular biology and biochemistry Cell culture and transfection Lab managerial and maintenance duties Assists faculty in the conduct of research of significant value in the basic and/or translational science area Plans, conducts research projects within the federal, institutional regulations and policies Collaborates with researchers, external agencies and institutions to develop cooperative research initiatives Trains technical staff, students in lab procedures Drafts and reviews manuscripts for peer-reviewed journals Assists with the submission of grant applications, contracts and research projects funding Participates in free discussion, research progress, and overall lab morale Responsible for appropriate use of research funds May supervise students or other research staff as assigned Education Qualifications High School Diploma / GED Required Bachelor's Degree Preferred Experience Qualifications At least one (1) year of related classroom experience or successful completion of a technical training program (eg. Wistar, WPSI) and research laboratory experience Required At least two (2) years of related classroom experience or successful completion of a technical training program (eg. Wistar, WPSI) and research la oratory experience Preferred Skills and Abilities Intermediate understanding of lab procedures, protocols, and equipment. Basic exposure to lab specific experiments / techniques and scientific analysis Excellent verbal and written communications skills Excellent organizational skills Solid critical thinking / problem-solving skills Solid analytical skills

To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must be fully vaccinated against COVID-19 and receive an annual influenza vaccine. Learn more.

Employees may request exemptions for valid religious and medical reasons. Start dates may be delayed until candidates are immunized or exemption requests are reviewed.

EEO / VEVRAA Federal Contractor |  Tobacco Statement

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.