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Reference #: 1010210 SHIFT:Day (United States of America)

Seeking Breakthrough Makers Children's Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation. At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care-and your career. CHOP's Commitment to Diversity, Equity, and Inclusion CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children. We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.

A Brief Overview The Bioinformatics Scientist III position is an intermediate level position for a PhD level professional and a final stage position for those with high experience without a PhD. The focus of the position is collaboration-level application of bioinformatics tools and methods to bench and clinical research problems in various biomedical domains. The position allows for a wide variety of activities described within the job responsibilities and encompasses positions within both research and clinical environments. Activities occur with a low degree of supervision with expectation for highly independent judgment, development of bioinformatics workflows and processes, and presentation of results. The Bioinformatics Scientist III will apply best practices in collaborative science as a bioinformatics domain scientific collaborator. Academic output is a focus of this position and is expected with a low degree of supervision. The Bioinformatics Scientist III is primarily focused on taking a lead, proactive scientific role in teams and projects as a bioinformatics domain expert. The Bioinformatics Scientist III must be able to perform all responsibilities listed in the Bioinformatics Scientist II job description. All responsibilities listed in this description are additional.

What you will do Pre-Analysis (10%): Actively participate in the development of application portfolio by developing knowledge of internally developed systems, open-source programs, and commercial applications. Provide efficient data management support. Lead development of additional pipeline functionality and changes by providing knowledge of both collaboration-specific requirements and bioinformatics discipline advances Coding (10%): Code and generally support code and applications on behalf of collaborative project and/or team. Master best practices for project-based code development, QC, and execution consist with the expectations of specific collaborations Lead peer-to-peer code reviews by participating in informal and formal critical code reviews Data Analysis (30%): Analyze data of high complexity by applying sound statistical and commonly accepted bioinformatics methods to -omics data primarily under the direction of the collaborative project team Lead regular peer-to-peer review of analysis plans in both informal and formal settings Develop multiple specialty analytical areas that serve one or more collaborative teams Lead adoption of best practices in specialty analytical or biomedical areas by the bioinformatics group and peers Collaboration (30%): Lead bioinformatics portion of scientific collaborations as the primary bioinformatics resource As bioinformatics point, assume management role for projects of low-to-moderate complexity, including all aspects of timelines, risk identification and mitigation strategies, and communication mechanisms Directl manage all elements of project satisfaction and performance relative to scientific project aims Promote continual objective, hard discussions about overall health of project and relationship Develop new collaborations with moderate degree of supervision Academic Output (20%): Lead project-based presentations, grant sections, and manuscript sections with subsequent review by peers and mentors Regularly coordinate and write bioinformatics-focused manuscripts and publications Regularly coordinate and lead podium presentations and posters Proactively contribute to entire bioinformatics and other sections of grant and award proposalsEducation Qualifications Master's Degree  Required Doctorate biological or computational discipline Preferred  Experience Qualifications At least five (5) years experience in applied bioinformatics, genomics, and computational work. This experience can be inclusive of a relevant PhD dissertation. Required Skills and Abilities Ability to, under supervision, conceive of, plan, implement, validate, and disseminate entire research projects is required. Ability to assume principal investigator or similar role in academic research is preferred. Strong UNIX/LINUX expertise required. Proficiency in R or similar commonly used bioinformatics language required Experience with Python, Perl, or other languages required. Experience with pipeline or workflow development frameworks preferred. Experience with management and analysis of complex data types required. Proficiency in various open source and commercial bioinformatics resources and software required. Experience with genomic/proteomic data analysis methods required. Experience or knowledge of technologies commonly used in biological labs, such as PCR, cloning, electrophoresis gels, and cell culture required. Knowledge of the working mechanism of microarray, NGS, mass spectrometry, or other high-throughput technologies and awareness of their strengths and weaknesses, as well as applicability to a specific biological problem is required. Familiarity with resources of genomic data sets and analysis tools, such as UCSC Genome Browser, Bioconductor, ENCODE, and NCBI databases is required. Ability to correctly select and perform statistical tests for most types of genomic data, and to properly interpret their results in the scenario of a specific study is required. Ability to leverage unique knowledge of bioinformatics, applied biostatistics, molecular biology, and measurement platforms for effective scientific discussion with biologists and clinicians is required. Ability to determine most favorable academic output as a primary research outcome is preferred. Ability to objectively critique results and present as valid or questionable, taking into account all aspects of study design, technical issues, and limitations of workflows is required. Accountability and attention to timelines. Excellent organization and communication skills with an emphasis on strong presentation skills Ability to independently plan and execute analyses of moderate complexity required Ability to provide objective validation of results required Ability to work in a team environment. To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community.  As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must be fully vaccinated against COVID-19 and receive an annual influenza vaccine. Learn more. Employees may request exemptions for valid religious and medical reasons.  S